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Article

Life histories of myeloproliferative neoplasms inferred from phylogenies.

Nature - 1 Feb 2022

Williams Nicholas, Lee Joe, Mitchell Emily, Moore Luiza, Baxter E Joanna, Hewinson James, Dawson Kevin J, Menzies Andrew, Godfrey Anna L, Green Anthony R, Campbell Peter J, Nangalia Jyoti

Abstract excerpt

Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the timing of driver mutations and subsequent clonal dynamics is limited1-3. Here, using whole-genome sequencing of 1,013 clonal haematopoietic colonies from 12 patients with myeloproliferative neoplasms, we identified 580,133 somatic mutations to reconstruct haematopoietic phylogenies and determine clonal histories. Driver...

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PMID: 35058638
DOI: 10.1038/s41586-021-04312-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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