Genetic evolution of myeloproliferative neoplasms from chronic phase to blastic phase: An analysis of 46 paired samples

Abstract excerpt

BACKGROUND: Clonal evolution drives progression of myeloproliferative neoplasms (MPN) from chronic phase (CP) to blastic phase (BP). METHODS: Targeted next-generation sequencing of 46 paired MPN-CP/BP samples was performed to assess clonal evolution through variant allele frequency changes. RESULTS: The median time from MPN-CP to BP was 6.9 (range 0.3-27.8) years. In MPN-CP, driver mutation frequency was 98%...