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Article

[Clonal evolution in myeloproliferative neoplasms].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2024

Yoshida Kenichi

Abstract excerpt

Recent advances in sequencing technologies have clarified the driver gene landscape in Philadelphia chromosomenegative (Ph-) myeloproliferative neoplasms (MPNs) and progressed understanding of MPN pathogenesis. Beyond mutations in the main three drivers of MPN, namely JAK2, MPL and CALR, somatic mutations in the epigenetic regulators and RNA splicing factors have been identified and their association with...

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Clonal Evolution
Mutation
Myeloproliferative Disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39231709
DOI: 10.11406/rinketsu.65.784

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