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Article

Ph-chromosome-negative myeloproliferative neoplasms: clonal dynamics are the name of the game.

Blood reviews - 1 Apr 2026

Noorafrooz Mohammadamin, Noorafrooz Ramin, Barosi Giovanni, Gale Robert Peter

Abstract excerpt

Ph-chromosome-negative myelo-proliferative neoplasms (MPNs) are characterized by over-production of mature blood cells driven by acquired somatic variants in JAK2, CALR and MPL in most instances. Ph-chromosome-negative MPNs are genetically and clinically heterogeneous. These variants are detected in blood cells of > 3 per cent of normal people but few develop Ph-chromosome-negative MPNs. People with...

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Topics

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Share to Receptors, Thrombopoietin
Share to Clonal Evolution
Share to CALR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Janus Kinase 2

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Share to Myeloproliferative Disorders

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Source

Identifiers

PMID: 41813557
DOI: 10.1016/j.blre.2026.101385

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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