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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

10 Jul 2023

Abstract excerpt

We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinants for heart failure. Using the GWAS results and blood protein quantitative loci, we perform Mendelian randomization and colocalization analyses on human proteins to provide...

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PMID: 37429843
DOI: 10.1038/s41467-023-39253-3

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