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Article

Proteome-Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm.

Journal of the American Heart Association - 4 Feb 2025

Zhang Ka, Liu Yuan, Mao Aiqin, Li Changzhu, Geng Li, Kan Hao

Abstract excerpt

BACKGROUND: The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA). METHODS AND RESULTS: Our study used plasma proteomics data from the UK Biobank, comprising 2923 proteins from 54 219 individuals, and from deCODE Genetics, which measured...

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Share to Aortic Aneurysm, Abdominal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39895541
DOI: 10.1161/JAHA.124.038193
PMCID: PMC12074732

Genes

COL6A3
PRKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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