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Article

Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization.

American journal of hypertension - 16 Sept 2025

Pan Wei, Huang Daoxin, Lin Chunjin, Huang Haozhang, Chen Qing, Wang Liman, Li Min, Yu Huizhen

Abstract excerpt

BACKGROUND: Hypertension (HT) is the most prevalent risk factor for cardiovascular disease (CVD) worldwide. Despite being a highly heritable trait, the underlying mechanisms of HT remain elusive due to its complex genetic architecture. Discovering disease-associated proteins with causal genetic evidence offers a potential strategy for identifying therapeutic targets for HT. METHODS: We analyzed the plasma...

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Antihypertensive Agents
Blood Pressure
Blood Proteins
Genome-Wide Association Study
Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Quantitative Trait Loci

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PMID: 39844355
DOI: 10.1093/ajh/hpaf011

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ERAP1
ACVRL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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