Whole genome sequencing of endometrial cancer identifies novel subgroups, drivers, and actionable alterations

Abstract excerpt

<h4>ABSTRACT</h4> Endometrial cancer (EC) is the most common gynaecological malignancy in high income countries, and is increasing in incidence. While molecular stratification has improved its management, precision care is hampered by incomplete characterization of the EC genome. We address this by analysis of whole genome sequencing (WGS) of 665 ECs generated by the UK Genomics England 100,000 Genome Project (10...

Topics

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• Adenocarcinoma, Clear Cell
• Carcinoma, Endometrioid
• Endometrial Neoplasms
• F-Box-WD Repeat-Containing Protein 7
• Genetic Predisposition to Disease
• Genomics
• Mutation
• Uterine Neoplasms

Identifiers and source

Literature Corpus work

32ba8a5b-b160-5c7d-bddd-441d697915ef

DOI

10.64898/2026.06.15.730391