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Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4’s oncogenic role

25 Jul 2025

Abstract excerpt

Background Glioblastoma (GBM) was considered the most aggressive type of primary brain tumor, marked by poor clinical outcomes and a high tendency to relapse. The therapeutic efficacy of GBM was significantly compromised by tumor heterogeneity, dysregulated metabolic pathways, the formation of an immunosuppressive microenvironment, and treatment resistance. Therefore, multi-dimensional therapeutic strategies...

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Glioma Diagnosis and Treatment
Neuroinflammation and Neurodegeneration Mechanisms
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40787449
DOI: 10.3389/fimmu.2025.1614549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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