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Transfer learning of an <i>in vivo-</i> derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies

2022-03-25

Abstract excerpt

Senescent cells (SnCs) contribute to normal tissue development and repair but accumulate with aging where they are implicated in a number of pathologies and diseases. Despite their pathological role and therapeutic interest, SnC phenotype and function in vivo remains unclear due to the challenges in identifying and isolating these rare cells. Here, we developed an in vivo -derived senescence gene expression sign...

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Literature Corpus work
305f12e8-81a4-52e8-8f80-343a15f10c34
DOI
10.1101/2022.03.22.485297
Open publication

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Transfer learning of an <i>in vivo-</i> derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologiesDOI 10.1101/2022.03.22.485297
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