A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Abstract excerpt

Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell identification remains challenging. Here, we generate a gene set (SenMayo) and validate its enrichment in bone biopsies from two aged human cohorts. We further demonstrate reductions in SenMayo in bone following genetic clearance of senescent cells in mice and in...

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• Share to Genetics, Aging, and Longevity in Model Organisms
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