Article

Uncovering senescent fibroblast heterogeneity connects DNA damage response to idiopathic pulmonary fibrosis

2025-11-30

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a largely heterogeneous state of cell stress that deleteriously accumulates with age. Many types of heterogeneity in senescence have been described; however, cellular senescence within the same cell type has only started to be documented. Here, we show primary, human lung fibroblasts from donors who are healthy or diagnosed with idiopathic pulmonary fibrosis (IPF) exhibit...

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Literature Corpus work: 5d781b6a-f81a-5eb1-b65c-0bd21689f6f7
DOI: 10.1101/2025.11.26.690792

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