Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

Abstract excerpt

Compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may precipitate fibrosis. While increased markers of senescence have been reported in idiopathic pulmonary fibrosis (IPF), the origin and identity of these senescent cells remain unclear, and tools to characterize context-specific cellular senescence in human lung are lacking. We observed that the senescent marker...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Neonatal Respiratory Health Research
• Share to Telomeres, Telomerase, and Senescence