Article

Structural basis of substrate recognition and translocation by human ABCD1

2021-09-24

Abstract excerpt

Human ATP-binding cassette (ABC) transporter ABCD1 transports CoA esters of saturated/monounsaturated very long chain fatty acid from cytosol to the peroxisome for β-oxidation. Dysfunction of human ABCD1 usually causes the severe progressive genetic disorder X-linked adrenoleukodystrophy, which eventually affects the adrenal glands and/or the central nervous system. Here, we report three cryo-EM structures of huma...

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Literature Corpus work: 305695b0-4406-59a5-bc55-1716d9af96a3
DOI: 10.1101/2021.09.24.461565

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