Article

ATP and Substrate Binding Regulates Conformational Changes of Human Peroxisomal ABC Transporter ALDP

2021-11-09

Abstract excerpt

The malfunction of ABCD1 causes X-linked adrenoleukodystrophy (X-ALD), a rare neurodegenerative disease that affect all tissues in human. Residing in the peroxisome membrane, ABCD1 plays a role in the translocation of very long chain fatty acids (VLCFA) for their damage by β-oxidation. Here, we present five Cryo-Electron microscopy structures of ABCD1 in four conformational states. Combined with functional analysi...

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Identifiers and source

Literature Corpus work: c01f97ef-6db6-510d-964d-62ba588937b5
DOI: 10.21203/rs.3.rs-1002426/v1

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