Article

Structure insights of the human peroxisomal ABC transporter ALDP

2021-09-25

Abstract excerpt

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of free very-long-chain fatty acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane. ALDP belongs to the ATP-binding cassette sub-family D, which is also named as ABCD1. Dysfunction of ALDP leads to peroxisomal metabolic disorder exemplified by X-linked adrenoleukodystrophy (ALD). Hundreds of ALD-causing mutations are identi...

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Literature Corpus work: 1a6f0c6a-e4c9-5417-b6e3-cc02ca052b70
DOI: 10.1101/2021.09.24.461756

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