Article

Structural basis for catalysis and substrate specificity of human ACAT1

2020-01-06

Abstract excerpt

<h4>Summary</h4> Acyl-coenzyme A: cholesterol acyltransferases (ACATs) catalyze acyl transfer from acyl-coenzyme A (CoA) to cholesterol to generate cholesteryl ester, which is the primary form for cellular storage and plasma transport of cholesterol. Because of their close relationship with cholesterol metabolism, ACATs represent potential drug target for the treatment of atherosclerosis and other cholesterol-rel...

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Literature Corpus work: abf3871e-0b56-5427-9291-85832de70701
DOI: 10.1101/2020.01.06.896597

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