Article

Molecular mechanism of substrate transport by human peroxisomal ABCD3

2025-05-27

Abstract excerpt

Peroxisomes are eukaryotic oxidative organelles involved in numerous metabolic functions that include fatty acid oxidation, bile acid synthesis, and detoxification of reactive oxygen species. ATP-binding cassette transporters of the D subfamily (ABCD1-3) mediate the import of CoA thioesters of fatty acids into the peroxisome. ABCD3, the most abundant of these transporters in the peroxisomal membrane, facilitates t...

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Literature Corpus work: a514dc03-32db-56f0-af50-df620b69ed42
DOI: 10.1101/2025.05.21.655323

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