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Article

Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

2021-09-04

Abstract excerpt

The peroxisomal very long chain fatty acid (VLCFA) transporter ABCD1 is central to cellular fatty acid catabolism and lipid biosynthesis. Its dysfunction underlies toxic cytosolic accumulation of VLCFAs, progressive nervous system demyelination, and neurological impairments including the potentially fatal disease X-linked adrenoleukodystrophy (X-ALD). Molecular details underlying substrate recognition and transpor...

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Literature Corpus work
1b6ef741-de2a-58da-b8eb-cc9892b64df0
DOI
10.1101/2021.09.04.458904
Open publication

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