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Article

Activity and Structural Dynamics of Human ABCA1 in a Lipid Membrane.

Journal of molecular biology - 15 Apr 2023

Plummer-Medeiros Ashlee M, Culbertson Alan T, Morales-Perez Claudio L, Liao Maofu

Abstract excerpt

The human ATP-binding cassette (ABC) transporter ABCA1 plays a critical role in lipid homeostasis as it extracts sterols and phospholipids from the plasma membrane for excretion to the extracellular apolipoprotein A-I and subsequent formation of high-density lipoprotein (HDL) particles. Deleterious mutations of ABCA1 lead to sterol accumulation and are associated with atherosclerosis, poor cardiovascular...

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Share to Apolipoprotein A-I
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipid Bilayers

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Source

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Identifiers

PMID: 36889459
DOI: 10.1016/j.jmb.2023.168038
PMCID: PMC11540065

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