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Article

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.

Nature reviews. Cancer - 1 Jun 2015

Rao Rajesh C, Dou Yali

Abstract excerpt

Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility. Although the human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member KMT2A in this disease, recent...

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Identifiers

PMID: 25998713
DOI: 10.1038/nrc3929
PMCID: PMC4493861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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