Article
Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.
Haematologica - 1 Jan 2022
Milan Thomas, Celton Magalie, Lagacé Karine, Roques Élodie, Safa-Tahar-Henni Safia, Bresson Eva, Bergeron Anne, Hebert Josée, Meshinchi Soheil, Cellot Sonia, Barabé Frédéric, Wilhelm Brian T
Abstract excerpt
Chromosomal translocations involving KMT2A gene are one of the most common genetic alterations found in pediatric acute myeloid leukemias (AML) although the molecular mechanisms that initiate the disease remain incompletely defined. To elucidate these initiating events we have used a human model system of AML driven by the KMT2A-MLLT3 (KM3) fusion. More specifically, we investigated changes in DNA methylation,...
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