Article
KMT2A rearranged acute lymphoblastic leukaemia: Unravelling the genomic complexity and heterogeneity of this high-risk disease.
Cancer letters - 28 Jan 2020
Forgione Michelle O, McClure Barbara J, Eadie Laura N, Yeung David T, White Deborah L
Abstract excerpt
KMT2A rearranged (KMT2Ar) acute lymphoblastic leukaemia (ALL) is a high-risk genomic subtype, with long-term survival rates of less than 60% across all age groups. These cases present a complex clinical challenge, with a high incidence in infants, high-risk clinical features and propensity for aggressive relapse. KMT2A rearrangements are highly pathogenic leukaemic drivers, reflected by the high incidence of...
Topics
- Animals
- Gene Rearrangement
- Genetic Heterogeneity
- Genomics
- High-Throughput Nucleotide Sequencing
- Histone-Lysine N-Methyltransferase
- Humans
- Mice
- Mutation
- Myeloid-Lymphoid Leukemia Protein