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Role of Chromosomal Microarray and RNA Fusion Analysis in Detecting <i>KMT2A</i>-PTD and Stem Cell Transplant Impact on Mortality

2025-05-28

Abstract excerpt

KMT2A partial tandem duplication ( KMT2A -PTD) is a recurrent, high-risk alteration in myeloid neoplasms, yet no gold standard exists for its detection due to complex genomic architecture. We conducted a retrospective study of 97 specimens from 17 patients with KMT2A -PTD-positive myeloid neoplasms (11 AML, 4 MDS, 2 MPN) to compare chromosomal microarray analysis (CMA) and RNA fusion testing. Overall concordance w...

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Literature Corpus work
1324c52c-632b-56b2-ba78-1ddce9d6f489
DOI
10.1101/2025.05.27.25328455
Open publication

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Role of Chromosomal Microarray and RNA Fusion Analysis in Detecting <i>KMT2A</i>-PTD and Stem Cell Transplant Impact on MortalityDOI 10.1101/2025.05.27.25328455
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