Article

Extensive co-regulation of neighbouring genes complicates the use of eQTLs in target gene prioritisation

2023-09-30

Abstract excerpt

Identifying causal genes underlying genome-wide association studies (GWAS) is a fundamental problem in human genetics. Although colocalisation with gene expression quantitative trait loci (eQTLs) is often used to prioritise GWAS target genes, systematic benchmarking has been limited due to unavailability of large ground truth datasets. Here, we re-analysed plasma protein QTL data from 3,301 individuals of the INTE...

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Literature Corpus work: 0351e81b-51d8-5954-ae9a-c2a0212dbdda
DOI: 10.1101/2023.09.29.560109

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