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Article

Extensive co-regulation of neighboring genes complicates the use of eQTLs in target gene prioritization.

HGG advances - 10 Oct 2024

Tambets Ralf, Kolde Anastassia, Kolberg Peep, Love Michael I, Alasoo Kaur

Abstract excerpt

Identifying causal genes underlying genome-wide association studies (GWASs) is a fundamental problem in human genetics. Although colocalization with gene expression quantitative trait loci (eQTLs) is often used to prioritize GWAS target genes, systematic benchmarking has been limited due to unavailability of large ground truth datasets. Here, we re-analyzed plasma protein QTL data from 3,301 individuals of the...

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Identifiers

PMID: 39210598
DOI: 10.1016/j.xhgg.2024.100348
PMCID: PMC11416642

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