Article

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

2018-11-20

Abstract excerpt

It is widely known that regulatory variation plays a major role in complex disease and that cell-type-specific binding of transcription factors (TF) is critical to gene regulation, but genomic annotations from directly measured TF binding information are not currently available for most cell-type-TF pairs. Here, we construct cell-type-specific TF binding annotations by intersecting sequence-based TF binding predic...

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Literature Corpus work: 2ba85ac6-58e3-51bb-b3a4-4b8131953b91
DOI: 10.1101/474684

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