Article

Disentangling effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex trait loci

2014-09-18

Abstract excerpt

Identifying genomic annotations that differentiate causal from associated variants is critical to fine-map disease loci. While many studies have identified non-coding annotations overlapping disease variants, these annotations colocalize, complicating fine-mapping efforts. We demonstrate that conventional enrichment tests are inflated and cannot distinguish causal effects from colocalizing annotations. We develope...

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Literature Corpus work: 8f2caa06-446e-5467-afac-9a0a73b4c88b
DOI: 10.1101/009258

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