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Article

A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics.

American journal of human genetics - 2 Nov 2023

Zhang Zixuan, Jung Junghyun, Kim Artem, Suboc Noah, Gazal Steven, Mancuso Nicholas

Abstract excerpt

Genome-wide association studies (GWASs) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While methods have been proposed to characterize pleiotropic components across groups of phenotypes, scaling these approaches to ultra-large-scale biobanks has been challenging. Here, we propose FactorGo, a scalable variational factor analysis model to identify and...

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Identifiers

PMID: 37879338
DOI: 10.1016/j.ajhg.2023.09.015
PMCID: PMC10645558

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