Article

Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells

2025-07-27

Abstract excerpt

<h4>ABSTRACT</h4> Nucleases are emerging as promising pharmacological targets due to their essential role in maintaining genomic stability, which is crucial for cellular viability and can be exploited in the prevention and treatment of various diseases, including cancer. The conserved structure-specific endonuclease MUS81 is required for resolving branched DNA intermediates during replication, repair, and recombi...

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Literature Corpus work: 2f7932a0-a56f-5cf8-8999-d8bffae6a3f6
DOI: 10.1101/2025.07.25.666773

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