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Article

Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy

20 Jul 2022

Abstract excerpt

DNA damage repair plays a key role in maintaining genomic stability and integrity. Flap endonuclease 1 (FEN1) is a core protein in the base excision repair (BER) pathway and participates in Okazaki fragment maturation during DNA replication. Several studies have implicated FEN1 in the regulation of other DNA repair pathways, including homologous recombination repair (HRR) and non-homologous end joining (NHEJ)....

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PMID: 35883563
DOI: 10.3390/biom12071007

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