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Article

The Multifaceted Roles of Ku70/80

16 Apr 2021

Abstract excerpt

DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous or exogenous stresses. DSBs are also genetically programmed events during the V(D)J recombination process, meiosis, or other genome rearrangements, and they are intentionally generated to kill cancer during chemo- and radiotherapy. Most DSBs are processed in mammalian cells by the classical nonhomologous end-joining (c-NHEJ)...

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PMID: 33923616
DOI: 10.3390/ijms22084134

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