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UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair

2025-06-17

Abstract excerpt

<h4>SUMMARY</h4> DNA double-strand breaks (DSBs) are highly cytotoxic lesions whose misrepair can lead to genomic instability, cancer and developmental disorders. Through systematic screening of understudied ubiquitin-like modifiers (UBLs), we identify UFM1 as a previously unrecognised regulator of non-homologous end-joining (NHEJ). Using a structure-guided chemical biology strategy, we develop a photo-crosslinka...

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Literature Corpus work
7cfa6d99-983c-55b9-8e69-31b344ed1a14
DOI
10.1101/2025.06.16.659844
Open publication

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UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repairDOI 10.1101/2025.06.16.659844
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