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Article

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

PloS one - 1 Jan 2017

Ward Thomas A, McHugh Peter J, Durant Stephen T

Abstract excerpt

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human cancer cell-lines identify colorectal and gastric cell-lines with microsatellite instability (MSI) as enriched for...

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Source

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Identifiers

PMID: 28628639
DOI: 10.1371/journal.pone.0179278
PMCID: PMC5476263

Genes

FEN1
ATM
RAD51

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