Article
R-loop processing via REXO4-RNaseH1-mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity.
Science advances - 20 Feb 2026
Yang Han, Nie Chen, Qin Yingyu, Liang Xinxin, Chen Yifan, Zhou Zenan, Zhou Tao, Zhang Tao, Cui Yilin, Pang Ming, Wang Jiadong, Wang Weibin
Abstract excerpt
R-loop metabolism is closely associated with genome stability and tumors. Here, we identify an exonuclease REXO4, which collaborates with RNaseH1 endonuclease to degrade R-loops in an "endo/exo-cleavage coupling" manner. Specifically, REXO4 directly degrades the RNA strand in R-loops from the end or internal nick through its 3'-5' exonuclease activity and stimulates RNaseH1 endonuclease activity. The genome-wide...
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