Article

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

2019-11-12

Abstract excerpt

<h4>Background</h4> D-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical for the proliferation or homeostasis of tissues following the postnatal period is unknown. <h4>Methods</h4> To study PHGDH inhibition in adult animals, we developed a knock-in mouse model...

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Literature Corpus work: 2f5b56c0-7800-5f82-a78b-4f3b802929f7
DOI: 10.1101/838482

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