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Article

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.

Journal of lipid research - 1 Sept 2012

Borowsky Alexander D, Bandhuvula Padmavathi, Kumar Ashok, Yoshinaga Yuko, Nefedov Mikhail, Fong Loren G, Zhang Meng, Baridon Brian, Dillard Lisa, de Jong Pieter, Young Stephen G, West David B, Saba Julie D

Abstract excerpt

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. SPL generates a S1P chemical gradient that promotes lymphocyte trafficking and as such is being targeted to treat autoimmune diseases. Despite growing interest in SPL...

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Identifiers

PMID: 22781001
DOI: 10.1194/jlr.M028084
PMCID: PMC3413231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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