Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer

Abstract excerpt

Paraneoplastic syndromes arise when tumor-derived cytokines reprogram distant organs. Although mediators such as Interleukin-6 have been implicated, how these signals impair host organ function remains incompletely defined. Here, we identify a cytokine-lipid axis that drives hepatic autophagy dysfunction. Specifically, in Drosophila , the gut tumor-derived interleukin-like cytokine Upd3 induces the expression of...

Topics

Open a Topic to create a Post that cites this publication.

• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Inflammasome and immune disorders
• Lipid metabolism and biosynthesis
• Mitochondrial Function and Pathology
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

c26c8c00-7ef4-5018-a1af-5707ac371f8f

DOI

10.1101/2025.10.01.679814