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Article

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

ACS chemical biology - 20 Feb 2015

Fan Jing, Teng Xin, Liu Ling, Mattaini Katherine R, Looper Ryan E, Vander Heiden Matthew G, Rabinowitz Joshua D

Abstract excerpt

Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting possible additional growth-promoting roles for the enzyme. Here we show that, in addition to catalyzing oxidation of...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25406093
DOI: 10.1021/cb500683c
PMCID: PMC4340346

Genes

PHGDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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