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Article

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.

International journal of molecular sciences - 30 Sept 2021

Spohner Anna Katharina, Jakobi Katja, Trautmann Sandra, Thomas Dominique, Schumacher Fabian, Kleuser Burkhard, Lütjohann Dieter, El-Hindi Khadija, Grösch Sabine, Pfeilschifter Josef, Saba Julie D, Meyer Zu Heringdorf Dagmar

Abstract excerpt

Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of Sgpl1 in humans and mice leads to accumulation of sphingolipids and multiple organ injuries. Here, we addressed the role of hepatocyte Sgpl1 for regulation of sphingolipid homoeostasis by generating mice with hepatocyte-specific deletion of Sgpl1 (Sgpl1HepKO mice)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34638955
DOI: 10.3390/ijms221910617
PMCID: PMC8508615

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