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Article

Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality.

The Journal of biological chemistry - 30 Jan 2004

Yoshida Kazuyuki, Furuya Shigeki, Osuka Soh, Mitoma Junya, Shinoda Yoko, Watanabe Masahiko, Azuma Norihiro, Tanaka Hideyuki, Hashikawa Tsutomu, Itohara Shigeyoshi, Hirabayashi Yoshio

Abstract excerpt

D-3-Phosphoglycerate dehydrogenase (Phgdh; EC 1.1.1.95) is the first committed enzyme of L-serine biosynthesis in the phosphorylated pathway. To determine the physiological importance of Phgdh-dependent L-serine biosynthesis in vivo, we generated Phgdh-deficient mice using targeted gene disruptio...

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PMID: 14645240
DOI: 10.1074/jbc.C300507200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14645240-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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