Article
Increased PHGDH expression promotes aberrant melanin accumulation.
BMC cancer - 22 Jul 2019
Mattaini Katherine R, Sullivan Mark R, Lau Allison N, Fiske Brian P, Bronson Roderick T, Vander Heiden Matthew G
Abstract excerpt
BACKGROUND: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. METHODS: In order to study the effect of increased PHGDH expression in tissues in vivo, we generated mice harboring a PHGDHtetO allele that allows tissue-specific, doxycycline-inducible PHGDH expression, and we...
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