Article

Telomerase deficiency in humans is associated with systemic age-related changes in energy metabolism

2022-02-28

Abstract excerpt

<h4>SUMMARY</h4> Underlying mechanisms of plasma metabolite signatures of human ageing and age-related diseases are not clear but telomere attrition and dysfunction are central to both. Dyskeratosis Congenita (DC) is associated with mutations in the telomerase enzyme complex ( TERT , TERC , DKC1 ) and progressive telomere attrition. We show extracellular citrate is repressed by canonical telomerase function i...

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Literature Corpus work: 2f08183e-6d06-535f-bd83-ebcee3988225
DOI: 10.1101/2022.02.28.481982

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