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Metabolic Alterations in Cellular Senescence: The Role of Citrate in Ageing and Age-Related Disease

26 Mar 2022

Abstract excerpt

Recent mouse model experiments support an instrumental role for senescent cells in age-related diseases and senescent cells may be causal to certain age-related pathologies. A strongly supported hypothesis is that extranuclear chromatin is recognized by the cyclic GMP-AMP synthase-stimulator of interferon genes pathway, which in turn leads to the induction of several inflammatory cytokines as part of the...

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PMID: 35409012
DOI: 10.3390/ijms23073652

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