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Article

Dyskeratosis Congenita Links Telomere Attrition to  Age-Related Systemic Energetics.

The journals of gerontology. Series A, Biological sciences and medical sciences - 11 May 2023

James Emma Naomi, Sagi-Kiss Virag, Bennett Mark, Mycielska Maria Elzbieta, Karen-Ng Lee Peng, Roberts Terry, Matta Sheila, Dokal Inderjeet, Bundy Jacob Guy, Parkinson Eric Kenneth

Abstract excerpt

The underlying mechanisms of plasma metabolite signatures of human aging and age-related diseases are not clear but telomere attrition and dysfunction are central to both. Dyskeratosis congenita (DC) is associated with mutations in the telomerase enzyme complex (TERT, TERC, and DKC1) and progressive telomere attrition. We analyzed the effect of telomere attrition on senescence-associated metabolites in...

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Identifiers

PMID: 36651908
DOI: 10.1093/gerona/glad018
PMCID: PMC10172980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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