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Article

Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype.

Journal of leukocyte biology - 4 Nov 2024

Elfiky Ahmed M I, Canñizares Jessica López, Li Jiarong, Li Yim Andrew Y F, Verhoeven Arthur J, Ghiboub Mohammed, de Jonge Wouter J

Abstract excerpt

The metabolic profile of dendritic cells (DCs) shapes their phenotype and functions. The carboxylesterase 1 (CES1) enzyme is highly expressed in mononuclear myeloid cells; however, its exact role in DCs is elusive. We used a CES1 inhibitor (WWL113) and genetic overexpression to explore the role of CES1 in DC differentiation in inflammatory models. CES1 expression was analyzed during CD14+ monocytes...

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PMID: 38869086
DOI: 10.1093/jleuko/qiae137

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