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Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy

14 Jul 2022

Abstract excerpt

The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR) is identified as a urinary metabolite associated with risk and prognosis in lung and liver cancer. However, the source of high CR levels in patients with cancer as well as their implications for the treatment of these aggressive cancers remain unclear. By...

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PMID: 35838048
DOI: 10.1172/jci157410

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