Article
Mitochondrial metabolism and epigenetic crosstalk drive SASP.
Nature - 1 Aug 2026
Martini Hélène, Birch Jodie, Marques Francisco D M, Victorelli Stella, Lagnado Anthony B, Pirius Nicholas, Franco Ana Catarina, Lee Gung, Han Yeaeun, Rowsey Jennifer L, Ismail Wazim Mohammed, Mazzone Amelia, Espe Tianna M, Hitosugi Taro, Li Ya, Washington Alexander M, Havas Aaron, Murad Rabi, Lei Xue, Porritt Rebecca A, Maddocks Oliver D K, Machado Espindola-Netto Jair, Saul Dominik, Khosla Sundeep, Jurk Diana, Kostallari Enis, Gaspar-Maia Alexandre, Adams Peter D, Passos João F
Abstract excerpt
Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP)1. Cytosolic mitochondrial nucleic acids activate innate immune signalling to initiate this inflammatory programme2,3. Here we show that mitochondrial metabolism provides a second layer of control that enables execution of the inflammatory programme. In senescent cells, the mitochondrial...
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