Article
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
The EMBO journal - 2 Nov 2020
Sun Chongkui, Wang Kun, Stock Amanda J, Gong Yi, Demarest Tyler G, Yang Beimeng, Giri Neelam, Harrington Lea, Alter Blanche P, Savage Sharon A, Bohr Vilhelm A, Liu Yie
Abstract excerpt
Short telomeres are a principal defining feature of telomere biology disorders, such as dyskeratosis congenita (DC), for which there are no effective treatments. Here, we report that primary fibroblasts from DC patients and late generation telomerase knockout mice display lower nicotinamide adenine dinucleotide (NAD) levels, and an imbalance in the NAD metabolome that includes elevated CD38 NADase and reduced...
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