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Membrane transporter Progressive Ankylosis Protein Homolog ( <i>ANKH</i> / <i>Ank</i> ) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing

2024-08-30

Abstract excerpt

A considerable body of recent evidence supports citrate transport as a major regulator of organismal lifespan and healthspan. Citrate accumulates outside senescent cells in vitro and in vivo . However, the detailed mechanism of senescent cell extracellular citrate (EC) accumulation is not clear. We show here that EC is partially mediated by a newly described plasma membrane citrate transporter ANKH/SLC62A1 (pro...

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Literature Corpus work
3f53fbc6-6447-5999-abcf-0c0efe95b79b
DOI
10.1101/2024.08.30.609895
Open publication

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Membrane transporter Progressive Ankylosis Protein Homolog ( <i>ANKH</i> / <i>Ank</i> ) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageingDOI 10.1101/2024.08.30.609895
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